Which genetic condition results in a lack of clotting factors in the blood?

Hemophilia is a genetic condition characterized by a deficiency of specific clotting factors required for normal blood coagulation. This condition is typically inherited in an X-linked recessive pattern, which primarily affects males. Individuals with hemophilia find it difficult to form blood clots, leading to prolonged bleeding episodes after injuries or during surgeries. The severity of hemophilia can vary depending on the specific clotting factor that is deficient; the most common types are hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficiency).

The other conditions mentioned in the choices do not specifically refer to a lack of clotting factors. Sickle cell disease is related to abnormal hemoglobin in red blood cells, leading to various complications but not directly to clotting factor deficiencies. Thrombocytopenia refers to a low platelet count, which can lead to bleeding issues but is not caused by a deficiency of clotting factors themselves. Von Willebrand disease involves a deficiency or dysfunction of von Willebrand factor, which plays a role in platelet function and stabilizing clotting factor VIII, but it is not the same as the clotting factor deficiencies found in hemophilia. Thus, the correct answer highlights the specific impact of hemophilia on the